Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study
نویسندگان
چکیده
AbstractBackground and aims Lipoprotein(a) is an independent risk factor for cardiovascular disease recurrent ischemic stroke. levels are known to be associated with carotid artery stenosis, but the relation of lipoprotein(a) atherosclerotic plaque composition morphology less known. We hypothesize that higher lipoprotein(a)-related SNPs a more vulnerable this effect sex-specific. Methods In 182 patients Plaque At RISK study we determined concentrations, apo(a) KIV-2 repeats LPA SNPs. Imaging characteristics atherosclerosis were by MDCTA (n = 161) and/or MRI 171). Regressions analyses used investigate sex-stratified associations between levels, repeats, imaging characteristics. Results was presence lipid-rich necrotic core (LRNC) (aOR 1.07, 95% CI: 1.00; 1.15), thin-or-ruptured fibrous cap (TRFC) 1.01; 1.14), degree stenosis (? 0.44, 0.00; 0.88). women, intraplaque hemorrhage (IPH) 1.25, 1.06; 1.61). men, 0.58, 0.04; 1.12). Rs10455872 significantly increased calcification volume 0.25; 1.89) absence ulceration 0.25, 0.93). T3888P LRNC 0.36, 0.16; 0.78) smaller maximum vessel wall area -10.24, 95%CI: -19.03; -1.44). Conclusions symptomatic IPH, LRNC, TRFC, as characteristics, in artery. lower prevalence area. Further research larger populations needed confirm these results.
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2021
ISSN: ['0021-9150', '1879-1484']
DOI: https://doi.org/10.1016/j.atherosclerosis.2021.06.004